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  2. Biology
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  4. Oxygen Dissociation Curve
🧬 BiologyGraph

Oxygen Dissociation Curve

Plot the sigmoidal haemoglobin-oxygen dissociation curve. See the Bohr shift as pH falls, and compare haemoglobin with myoglobin.

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Key Concepts

  • • Haemoglobin's sigmoidal shape enables cooperative O₂ loading and unloading
  • • P₅₀: pO₂ at 50% saturation — lower P₅₀ = higher O₂ affinity
  • • Bohr effect: ↑CO₂ / ↓pH shifts curve right → Hb releases O₂ more readily (promotes delivery to active tissue)
  • • Myoglobin: hyperbolic curve, higher O₂ affinity than Hb — stores O₂ in muscles
  • • Foetal Hb (HbF) has higher affinity than adult Hb — curve lies to the left

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